Are aminosugars ototoxic?

Is Valproic Acid Ototoxic?

7 A forum for case studies, clinical notes and observations, and other clinical material that does not have a traditional research format. V alproic acid (VPA), or valproate, was first discovered in 1882 by Burton, but its anticonvulsant properties were not Although thousands of patients have been treated with VPA, only recently has the question of VPA ototoxicity been raised. The first reports...

Combined effects of noise and ototoxic drugs.

Although the treatment and rehabilitation of the hearing handicapped have reached highly sophisticated levels, man should not be overly impressed with his achievements. Two recently recognized causes of deafness are a result of our mechanized and "advanced" society. In nature sounds occurring louder than 100 decibels (dB) are a rarity; such intensities when frequently presented to the hearing m...

Ototoxic effects from gentamicin ear drops.

Linear polyethylenimine-plasmid DNA nanoparticles are ototoxic to the cultured sensory epithelium of neonatal mice.

Polyethylenimine (PEI) has been demonstrated to be an effective non‑viral synthetic polymer for efficient gene delivery amongst various cell types in vitro and in vivo. In the present study, 25 kDa linear PEI (L‑PEI) was used to transfer plasmid DNA (pDNA), encoding the enhanced green fluorescent protein reporter gene, into the cultured cochlear epithelium of neonatal mice. The 25 kDa L‑PEI/pDN...

Are Systemic Voriconazole and Caspofungin Ototoxic? An Experimental Study with Rats

OBJECTIVES To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity. METHODS This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR) thresholds of all animals were obtained under general anesthesia. Then, the rats were randomly divided into 4 groups (groups I-IV), each group consisting of 8 rats. Rat...